Herbicidal acetals and ketals

ABSTRACT

Novel furan- and thiophenesulfonamides such as 3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3-5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide are highly active pre-emergent and/or post-emergent herbicides.

This is a division of application Ser. No. 754,709, filed July 16, 1985,now U.S. Pat. No. 4,659,359, which, in turn, is a continuation-in-partof application U.S. Ser. No. 644,259, filed Aug. 27, 1984, nowabandoned.

BACKGROUND OF THE INVENTION

The present invention relates to a novel class of furan- andthiophenesulfonamide compounds and their use as pre-emergent andpost-emergent herbicides and as plant growth regulants.

U.S. Pat. Nos. 4,169,719 and 4,127,405 disclose herbicidal benzene-,furan- and thiophenesulfonamides of general formula ##STR1## where R₁may be an optionally substituted benzene or a furan or thiophenesubstituted with H, Cl, Br or CH₃.

U.S. Pat. No. 4,398,939 discloses herbicidal thiophenesulfonamides offormula ##STR2## where R is C₁ -C₄ alkyl, C₃ alkenyl, OCH₃, NO₂, Cl, Br,SO₂ NR₁ R₂ or SO₂ N(OCH₃)CH₃.

European Patent Application (EP-A) No. 30,142, published June 10, 1981discloses herbicidal furan- and thiophenesulfonamides of formula##STR3## where W' is O or S;

A is C(O)QR^(I) or C(═T)R^(II) ; and

A' is H, Cl, Br, C₁ -C₄ alkyl, OCH₃, NO₂ or CF₃.

U.S. Pat. No. 4,370,480 teaches herbicidal benzenesulfonamides ofgeneral formula ##STR4## where ##STR5##

No. EP-A-64,804, published Nov. 17, 1982, teaches herbicidal furan- andthiophenesulfonamides of general formula ##STR6## where R₁ is S(O)_(n)R₆ ; and

R₂ is H, Cl, Br or CH₃ ;

No. EP-A-13,480 discloses herbicidal pyridinesulfonamides of formula##STR7## where R₁ is H, Cl, Br, F, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄alkylthio, NO₂ or CO₂ R₅ ; and

R₂ is H, Cl, Br or CH₃.

No. EP-A-35,893 discloses herbicidal pyridinesulfonamides of formula##STR8## where R₁ is S(O)_(n) R₃ ; and

R₂ is H, Cl, F, Br, CH₃, OCH₃, CF₃, NO₂, CN or NH₂.

No. EP-A-97,122, published Dec. 28, 1983, discloses herbicidalsulfonamides of formula ##STR9## where X is O, S, NR₄ or CR₅ ═N; and

R₂ is H, C₁ -C₃ alkyl, haloalkyl, alkoxy, alkylthio, alkylsulfonyl,halogen, NO₂, CWR₈, SO₂ NR₆ R₇ or COR₉.

No. EP-A-95,925, published Dec. 7, 1983, and No. EP-A-87,780, publishedSept. 7, 1983, teach herbicidal pyrazole sulfonylureas.

No. EP-A-95,925 (published Dec. 7, 1983) and No. EP-A-87,780 (publishedSept. 7, 1983) teach herbicidal pyrazole sulfonylureas.

No. EP-A-126,711 (published Nov. 28, 1984; Swiss priority May 16, 1983)discloses herbicidal sulfonylureas of the formula ##STR10## wherein X isO, S, --NR₅, ##STR11## --CH═CH-- or an annelated phenyl ring; Z is O orS;

Q is halogen, C₁ -C₄ alkyl, cyano, etc.;

R₁ is H, halogen, NO₂ or a group ##STR12## etc.; R₆ is, inter alia, H orC₁ -C₄ alkyl; and

R₂ and R₃ can be, among other things, C₁ -C₄ alkyl or C₁ -C₄ alkoxy.

SUMMARY OF THE INVENTION

This invention relates to novel compounds of Formula I, agriculturallysuitable compositions containing them and their method-of-use aspreemergent and/or postemergent herbicides or plant growth regulants.##STR13## wherein Q is ##STR14## r is H or CH₃ ; R₁ is ##STR15## E isCH₂ or a single bond; R₂ is H, C₁ -C₂ alkyl or Cl;

R₃ is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy;

R₄ and R₅ are independently C₁ -C₂ alkyl;

R₆ and R₇ are independently H or C₁ -C₂ alkyl;

W is O or S;

W₁ is O or S;

Q₁ and Q₂ are independently O, S or NCH₃ ;

A is ##STR16## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy,C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂-C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃)alkylamino;

Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, C₃ -C₄alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylsulfinylalkyl, C₁ -C₄haloalkyl, C₂ -C₅ alkylsulfonylalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl,C₂ -C₅ alkylthioalkyl, C(O)R₈, ##STR17## N(OCH₃)CH₃ ; m is 2 or 3;

L₁ and L₂ are independently O or S;

R₈ is H or CH₃ ;

R₉ and R₁₀ are independently C₁ -C₂ alkyl;

R₁₁ is C₁ -C₃ alkyl;

R₁₂ is H, F, Cl, NO₂, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁-C₂ alkylsulfinyl, C₁ -C₂ alkylsulfonyl, di(C₁ -C₂)alkylsulfamoyl or CO₂(C₁ -C₂ alkyl);

R₁₃ is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F or NO₂ ;

R₁₄ is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkyl, C₁ -C₃haloalkoxy, Cl, Br, F, NO₂, di(C₁ -C₃)alkylsulfamoyl, C₁ -C₃ alkylthio,C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, amino, C₁ -C₃ alkylamino,di(C₁ -C₃)alkylamino, CH₂ OCH₃, CH₂ SCH₃ or CH₂ CN.

Z is CH or N;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H; and

Y₂ is H or CH₃ ;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₃ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, OCF₂ H, SCF₂ H, CH₃ or C₂ H₅ ;

X₃ is CH₃ or OCH₃ ;

Y₄ is CH₃, OCH₃, OC₂ H₅ or Cl; and

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;

and their agriculturally suitable salts; provided that

(a) when X is Cl, F, Br or I, then Z is CH and Y is OCH₃, OC₂ H₅,N(OCH₃)CH₃, NHCH₃, N(CH₃)₂ or OCF₂ H;

(b) when Y is cyclopropyl, X is other than Cl, F, Br or I;

(c) when R₃ is C₁ -C₃ alkoxy, then Q₁ and Q₂ are oxygen;

(d) when R₃ is H or C₁ -C₃ alkyl, then Q is Q-1 through Q-9;

(e) when X or Y is OCF₂ H, then Z is CH;

(f) when the total number of carbon atoms of X and Y is greater thanfour, then the combined number of carbons of the substituents on Q isless than or equal to ten;

(g) when W is S, then A is A-1, R is H, and Y is CH₃, OCH₃, OC₂ H₅, CH₂OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃,CH(OCH₃)₂ or ##STR18## (h) when A is A-7 and Z is N, then R₃ is C₁ -C₃alkoxy; (i) when E is CH₂, then R₁₄ is H, CH₃, OCH₃, Cl or NO₂ and isnot in the 4-position.

In the above definitions, the term "alkyl" used either alone or incompound words such as "alkylthio" or "haloalkyl", denotes straightchain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or thedifferent butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the differentbutoxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g., 1-propenyl,2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g., ethynyl,1-propynyl, 2-propynyl and the different butynyl isomers.

Cycloalkyl denotes cyclopropyl, cyclobutyl and cyclopentyl.

Term "halogen", either alone or in compound words such as "haloalkyl",denotes fluorine, chlorine, bromine or iodine.

In terms such as C₂ -C₅ alkoxyalkoxy, the specified number of carbonatoms is meant to define the total number of carbon atoms in thatsubstituent group. For example, C₂ -C₅ alkoxyalkoxy would represent OCH₂OCH₃ through O(CH₂)₄ OCH₃ or OCH₂ O(CH₂)₃ CH₃ and the various structuralisomers embraced therein.

Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the differentpropylsulfonyl isomers.

Alkylthio, alkylsulfinyl, alkylamino, alkylsulfamoyl, etc., are definedin an analogous manner.

PREFERRED COMPOUNDS

Preferred for reasons of the higher herbicidal efficacy, greater plantgrowth regulant activity and/or more favorable ease of synthesis are:

(1) Compounds of Formula I where

R₃ is H or C₁ -C₃ alkyl;

(2) Compounds of Formula I where

R₃ is C₁ -C₃ alkoxy;

(3) Compounds of Preferred 1 where

W is O;

R is H;

X is CH₃, OCH₃, OC₂ H₅, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂CHF₂, OCH₂ CF₃ or CF₃ ; and

Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃,N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃,CH₂ OC₂ H₅, ##STR19## OCF₂ H, C.tbd.CH, C.tbd.CCH₃, SCF₂ H orcyclopropyl;

(4) Compounds of Preferred 3 where

Q₁ and Q₂ are identical and are O or S;

R₁₂ is H, C₁ -C₂ alkyl or Cl;

R₁₃ is H; and

(5) Compounds of Preferred 4 where

A is A-1;

Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, NHCH₃, CH₂ OC₂ H₅, OCF₂ H, OCH₂CH₂ OCH₃, cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ; and

X is CH₃, OCH₃, Cl, OC₂ H₅, OCF₂ H or OCH₂ CF₃ ;

(6) Compounds of Preferred 5 where Q₁ and Q₂ are O;

(7) Compounds of Preferred 5 where Q₁ and Q₂ are S;

(8) Compounds of Preferred 5 where Q is Q-1;

(9) Compounds of Preferred 5 where Q is Q-2;

(10) Compounds of Preferred 5 where Q is Q-3;

(11) Compounds of Preferred 5 where Q is Q-4;

(12) Compounds of Preferred 5 where Q is Q-5;

(13) Compounds of Preferred 5 where Q is Q-6;

(14) Compounds of Preferred 5 where Q is Q-7;

(15) Compounds of Preferred 5 where Q is Q-8;

(16) Compounds of Preferred 5 where Q is Q-9;

(17) Compounds of Preferred 2 where

W is O;

R is H;

X is CH₃, OCH₃, OC₂ H₅, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂CHF₂, OCH₂ CF₃ or CF₃ ; and

Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃,N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃,CH₂ OC₂ H₅, ##STR20## OCF₂ H, SCF₂ H, cyclopropyl, C.tbd.CH orC.tbd.CCH₃ ;

(18) Compounds of Preferred 17 where

E is a single bond;

R₁₂ is H, C₁ -C₂ alkyl or Cl;

R₁₃ is H; and

R₁₄ is H, F, Cl, Br, C₁ -C₂ alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkylthio andis not para to the sulfonylurea bridge;

(19) Compounds of Preferred 18 where

A is A-1;

Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, NHCH₃, CH₂ OC₂ H₅, OCF₂ H, OCH₂CH₂ OCH₃, cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ; and

X is CH₃, OCH₃, Cl, OC₂ H₅, OCF₂ H or OCH₂ CF₃ ;

(20) Compounds of preferred 19 where Q is Q-1;

(21) Compounds of Preferred 19 where Q is Q-2;

(22) Compounds of Preferred 19 where Q is Q-3;

(23) Compounds of Preferred 19 where Q is Q-4;

(24) Compounds of Preferred 19 where Q is Q-5;

(25) Compounds of Preferred 19 where Q is Q-6;

(26) Compounds of Preferred 19 where Q is Q-7;

(27) Compounds of Preferred 19 where Q is Q-8;

(28) Compounds of Preferred 19 where Q is Q-9;

(29) Compounds of Preferred 19 where Q is Q-10;

Specifically Preferred for reasons of highest herbicidal efficacy and/ormost favorable ease of synthesis are:

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide,m.p. 164°-166° C.; and

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide,m.p. 137°-150° C.

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The compounds of Formula I can be prepared by one or more of the methodsshown in Equations 1-7.

As shown in Equation 1, compounds of Formula I (where W is O) can beprepared by treating sulfonamides of Formula II with phenyl esters ofN-heterocycliccarbamic acids of formula III in the presence of a strongorganic base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). ##STR21##wherein Q, R and A are as previously defined. The reaction of Equation 1is generally carried out in the range of 0° to 50° C. in an inertsolvent such as dioxane or acetonitrile, analogous to methods taught inEP-A No. 44,807. The required carbamates can be prepared from thecorresponding amines, IIIa, and diphenyl carbonate orphenylchloroformate and a base such as sodium hydride as shown inEquation 2. ##STR22##

Compounds of Formula I may also be prepared as shown in Equation 3 bytreating sulfonamides of Formula II with the methyl ester of anN-heterocycliccarbamic acid of Formula IIIb in the presence of anequimolar quantity of trimethylaluminum. ##STR23##

The reaction of Equation 3 is best carried out at temperatures between25° and 83° C. in a solvent such as methylene chloride or1,2-dichloroethane for 12 to 95 hours under an inert atmosphere, astaught in EP-A No. 84,244, published July 27, 1983. The methylcarbamates, IIIb, can be conveniently sythesized by treatment of thecorresponding heterocyclic amines of Formula IIIa with dimethylcarbonate or methyl chloroformate in the presence of a base such assodium hydride.

Alternatively, compounds of the Formula I can be prepared by thereaction of a sulfonylcarbamate of Formula IV with an aminoheterocycleof Formula IIIa as shown in Equation 4. ##STR24##

The reaction is carried out at 50° to 100° C. in a solvent such asdioxane for 0.5 to 24 hours as taught in No. EP-A-44,807. The requiredcarbamates of Formula IV are prepared by the reaction of thecorresponding sulfonamides of Formula II with diphenylcarbonate orphenylchloroformate in the presence of a base such as sodium hydride.

Compounds of Formula I, where W is S, can be prepared via addition of anappropriate heterocyclic amine, IIIa, to a sulfonyl isothiocyanate ofthe formula QSO₂ NCS. This reaction is best carried out according tomethods taught in U.S. Pat. No. 4,127,405.

Sulfonyl isothiocyanates of the formula QSO₂ NCS can be preparedaccording to the procedure of K. Hartke, Arch. Pharm., 299, 174 (1966).

Sulfonamides of Formula II used in the preparation of compounds ofFormula I are useful intermediates. They can be prepared by a variety ofmethods known in the art. For example, contacting an appropriatelysubstituted sulfonyl chloride IIa with ammonium hydroxide or ammonia inan inert solvent such as ether or tetrahydrofuran affords sulfonamidesII as shown by Equation 5a and 5b. ##STR25##

The reaction of sulfonyl chlorides, IIa, with ammonia is best carriedout at -33° to 50° C. for 0.1 to 24 hours. After removal of the ammoniumchloride by-product by filtration or extraction with water, the desiredproduct can be isolated by the evaporation of the organic solvent.

Ammonium hydroxide can be used in place of ammonia as in equation 5b.This reaction is widely reported in the literature, c.f., Methoden DerOrganischen Chemie (Houben-Weyl), Vol. 9, Ch. 19, edited by F. Muth,Stuttgart, 1955.

Alternatively, sulfonamides of Formula II can be prepared by thereaction of a lithium salt of an appropriately substituted sulfinicacid, IIb, with chloramine as shown in Equation 6. ##STR26##

This reaction can be carried out using the conditions referred to in thepreceding reference.

Lithium salts of Formula IIb can also be converted to the sulfonamidesof Formula IIa by the procedures taught in U.S. Pat. No. 4,441,910.

Sulfonyl chlorides of Formula IIa can be prepared by the reaction oflithium salts of Formula IIc with sulfuryl chloride at -50° to -20° C.in an inert solvent such as tetrahydrofuran or ether as shown inEquation 7. ##STR27##

Where R' is a group such a butyl, phenyl, diisopropylamino or similarmoiety commonly combined with lithium to form a lithiation agent. Theseagents and their method of use are described in N. S. Narasimhan and R.S. Mali, Synthesis, 957-86 (1983) or in The Chemistry of OrganolithiumCompounds, Wakefield, Pergamon Press, Oxford, 1974 or also H. W.Gschwend and H. R. Rodriguez, Org. React. 26, 1 (1978).

The sulfonyl chlorides, IIa, can be isolated by extracting the inorganicby-products with water followed by drying the organic layer over adrying agent such as magnesium sulfate, filtering the dried solution andevaporation of the solvent.

Lithium salts of Formula IIb can be prepared by contacting sulfurdioxide with the lithiated intermediate IIc using procedures describedin the above references on the lithiated intermediates.

The formation of orthoesters, acetals, cyclic acetals, thioacetals andtheir amino analogs where Q₁ or Q₂ are N--CH₃ is widely reported in theliterature, c.f.: Synthetic Organic Chemistry, R. B. Wagner and H. D.Zook, Ch. 8, John Wiley & Sons, New York, 1953; or Organic Synthesis, V.Migrdichian, Ch. 5, Reinhold, London, 1957.

The desired aldehyde and acetyl substituted thiophenes can be preparedby a variety of methods as described, for example, in "The Chemistry ofHeterocyclic Compounds". vol. 3, edited by H. D. Hartough, F. P.Hochgesang and F. F. Blicke, Interscience, N. Y., 1952. Pyrazolealdehydes and acetylpyrazoles can be prepared according to proceduresdescribed in "The Chemistry of Heterocyclic Compounds". Vol. 22, editedby R. H. Wiley, Interscience, N.Y., 1967. Aldehydes and acetylderivatives of furan can be prepared according to methods cited in"Advances in Heterocyclic Chemistry", Vol. 7, edited by A. R. Katritzkyand A. J. Boulton, and Vol. 30 edited by A. R. Katritzky, AcademicPress, N.Y., 1962 and 1982. Further references to the literature ofheterocyclic compounds can be found on pages 225-299 of Vol. 7 citedabove.

The heterocyclic amines of Formula IIIa can be prepared by methods knownin the literature, or simple modifications thereof, by those skilled inthe art. For instance, EP-A No. 84,224 (published July 27, 1983) and W.Braker et al., J. Am. Chem. Soc., 69, 3072 (1947) describes methods forpreparing aminopyrimidines and triazines substituted by acetal groupssuch as dialkoxymethyl or 1,3-dioxolan-2-yl, among other groups. Also,for example, South African patent application Nos. 82/5045 and 82/5671describe methods for preparing aminopyrimidines and triazinessubstituted by haloalkyl or haloalkylthio groups such as OCH₂ CH₂ F,OCH₂ CF₃, SCF₂ H, or OCF₂ H, among other groups, South African patentapplication No. 83/7434 (published Oct. 5, 1983) describes methods forthe synthesis of cyclopropylpyrimidines and triazines substituted bysuch groups as alkyl, haloalkyl, alkoxy, haloalkoxy, alkylamino,dialkylamino or alkoxyalkyl.

The 5,6-dihydrofuro[2.3-d]pyrimidin-2-amines, thecyclopenta[d]pyrimidin-2-amines (IIIa, A is A-2) and the6,7-dihydro-5H-pyrano[2.3-d]pyrimidin-2-amines (IIIa, A is A-3) can beprepared as described in EP-A No. 15,683. Thefuro[2.3-d]pyrimidin-2-amines (III, A is A-4) are described in EP-A No.46,677.

Compounds of Formula IIIa, where A is A-5, are described in EP-A No.73,562. Compounds of Formula IIIa, where A is A-6, are described in EP-ANo. 94,260. Compounds of Formula IIIa, where A is A-7, can be preparedby methods taught in EP-A No. 125,864.

In addition, general methods for preparing aminopyrimidines andtriazines have been reviewed in the following publications:

"The Chemistry of Heterocyclic Compounds," a series published byInterscience Publ., New York and London;

"Pyrimidines", Vol. 16 of the same series by D. J. Brown;

"s-Triazines and Derivatives," Vol. 13 of the same series by E. M.Smolin and L. Rapaport;

F. C. Schaefer, U.S. Pat. No. 3,154,547 and K. R. Huffman and F. C.Schaefer, J. Org. Chem., 28, 1812 (1963), which describes the synthesisof triazines.

Agriculturally suitable salts of compounds of Formula I are also usefulherbicides and can be prepared in a number of ways known in the art. Forexample, metal salts can be made by contacting compounds of Formula Iwith a solution of an alkali or alkaline earth metal salt having asufficiently basic anion (e.g., hydroxide, alkoxide or carbonate).Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formula I can also be prepared by exchange of onecation for another. Cationic exchange can be effected by direct contactof an aqueous solution of a salt of a compound of Formula I (e.g.,alkali of quaternary amine salt) with a solution containing the cationto be exchanged. This method is most effective when the desired saltcontaining the exchanged cation is insoluble in water and can beseparated by filtration.

Exchange may also be effected by passing an aqueous solution of a saltof a compound of Formula I (e.g., an alkali metal or quaternary aminesalt) through a column packed with a cation exchange resin containingthe cation to be exchanged for that of the original salt and the desiredproduct is eluted from the column. This methods is particularly usefulwhen the desired salt is water-soluble.

Acid addition salts, useful in this invention, can be obtained byreacting a compound of Formula I with a suitable acid, e.g.,p-toluenesulfonic acid, trichloroacetic acid or the like.

The preparation of the compounds of this invention is furtherillustrated by the following specific examples. Unless otherwiseindicated, temperatures are given in degrees centigrade.

EXAMPLE 1 3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonyl chloride

To 23.4 g of 3-(1,3-dioxolan-2-yl)thiophene (S. Gronowitz, et al.,Arkiv. Kemi., 20, 407 (1963)) in 100 ml of anhydrous tetrahydrofuran wasadded 100 ml of 1.6 molar n-butyllithium in hexane, with ice bathcooling. After stirring at room temperature for 20 minutes the mixturewas cooled to -78° and sulfuryl chloride (16.2 g) was then addeddropwise. This addition caused the suspended solids to form a tarry masswhich broke up when the mixture was allowed to warm to room temperature.After stirring one and one half hours at room temperature the mixturewas cooled to -10° and 10 ml of ethyl acetate was added dropwise. Thereaction mixture was then poured into ice water and extracted with ethylether. The ether portions were combined, dried over magnesium sulfate,filtered and the ether removed in-vacuo to yield 19.6 g of an oil.Infrared absorption spectra of this product showed peaks at 1330 and1180 cm⁻¹, consistent for the desired sulfonyl chloride. Mass spectrumanalysis: calc. 254, found 253 (Mass-1H) and the presence of a chlorineatom.

EXAMPLE 2 3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonamide

To 5 ml of liquified ammonia gas dissolved in 50 ml of tetrahydrofuranwas added dropwise with stirring and cooling 12.7 g of3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride. After stirringovernight at ambient temperature, the tetrahydrofuran was removed invacuo, water was added to the residue and the mixture was extractedtwice with 75 ml of methylene chloride. After washing the combinedmethylene chloride extracts with water, drying over magnesium sulfate,filtering off the drying agent and evaporation of the methylenechloride, an oily solid residue was obtained. This was chromatographedthrough silica gel using 1:1 ethyl acetate-hexanes as eluant (Rf 0.35).Evaporation of the solvent mixture yielded 2.2 g of the desired product,as a waxy solid. Infrared absorption spectra showed peaks at 3360, 3260,1340 and 1140 cm⁻¹, consistent for a primary sulfonamide. Mass spectrumanalysis: calc. 235, found 234 (Mass-1H).

EXAMPLE 3 3-(1,3-Dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide

To 0.47 g of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonamide in 20 ml ofacetonitrile was added 0.52 g ofphenyl(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate and 0.3 ml of1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). After stirring at ambienttemperatures for two hours the solution was diluted to 50 ml with waterand the pH was adjusted to 3 by the addition of hydrochloric acid. Theresultant solution was extracted with methylene chloride and themethylene chloride phase was dried over magnesium sulfate, filtered andevaporated. Trituration of the residue with butyl chloride yielded 0.6 gof the product, m.p. 164°-166°. Infrared absorption spectra showed peaksat 1700, 1600 and 1550 cm⁻¹, consistent for the desired structure.

NMR(CDCl₃): δ 2.56 (s, CH₃); 4.04 (s, OCH₃); 6.43 (s, ##STR28## 4.95 (t,(CH₂)₂); 7.25 (d, thiophene); 7.58 (d, thiophene).

EXAMPLE 4N-[4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide

To 0.47 g of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonamide in 20 ml ofacetonitrile was added 0.5 g of phenyl(4,6-dimethoxypyrimidin-2-yl)carbamate and 0.3 ml of DBU. After stirringfor two hours at ambient temperature, 25 ml of water was added to themixture and the solution was acidified to pH 3 with 10% hydrochloricacid. The precipitated product was removed by filtration, washed withwater and air dried to yield 0.9 g of the subject compound, m.p.157-168. Infrared absorption peaks at 1700, 1600, 1570 cm⁻¹ wereconsistent for the desired structure.

NMR(CDCl₃): δ 3.95 (m, CH₂ O); 3.95 (s, CH₃ O); 5.77 (s, pyrimidine);6.44 (s, dioxolane); 7.25 (d, thiophene); 7.57 (d, thiophene).

By using the procedures described in the foregoing equations andexamples or modifications thereof, one skilled in the art can preparethe compounds shown in the following tables.

                  TABLE OF STRUCTURES                                             ______________________________________                                         ##STR29##                                                                    GENERAL STRUCTURE I                                                            ##STR30##                                                                    GENERAL STRUCTURE Ia                                                           ##STR31##                                                                    GENERAL STRUCTURE Ib                                                           ##STR32##                                                                    GENERAL STRUCTURE Ic                                                           ##STR33##                                                                    GENERAL STRUCTURE Id                                                           ##STR34##                                                                    GENERAL STRUCTURE Ie                                                           ##STR35##                                                                    GENERAL STRUCTURE II                                                           ##STR36##                                                                    GENERAL STRUCTURE IIa                                                          ##STR37##                                                                    GENERAL STRUCTURE IIb                                                          ##STR38##                                                                    GENERAL STRUCTURE IIc                                                          ##STR39##                                                                    GENERAL STRUCTURE III                                                          ##STR40##                                                                    GENERAL STRUCTURE IIIa                                                         ##STR41##                                                                    GENERAL STRUCTURE IIIb                                                         ##STR42##                                                                    GENERAL STRUCTURE IV                                                           ##STR43##                                                                    GENERAL STRUCTURE IVa                                                          ##STR44##                                                                    GENERAL STRUCTURE IVb                                                          ##STR45##                                                                    GENERAL STRUCTURE V                                                            ##STR46##                                                                    GENERAL STRUCTURE Va                                                           ##STR47##                                                                    GENERAL STRUCTURE Vb                                                           ##STR48##                                                                    GENERAL STRUCTURE Vc                                                           ##STR49##                                                                    GENERAL STRUCTURE VI                                                           ##STR50##                                                                    GENERAL STRUCTURE VIa                                                          ##STR51##                                                                    GENERAL STRUCTURE VIb                                                          ##STR52##                                                                    GENERAL STRUCTURE VII                                                          ##STR53##                                                                    GENERAL STRUCTURE VIIa                                                        ______________________________________                                    

                                      TABLE I                                     __________________________________________________________________________    GENERAL STRUCTURE I                                                           R.sub.1     R.sub.2                                                                           R  W X      Y        Z  m.p. °C.                       __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CHF.sub.2                                                                  CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             NHCH.sub. 3                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                      N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(CH.sub.3)OCH.sub.3                                                                   N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             SCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.2 CH.sub.3                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.2 CH.sub.3                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             i-C.sub.3 H.sub.7                                                                      CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-                                                                          CH                                                                   2-yl                                              1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-2                                                                         N                                                                    2-yl                                              1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          N                                                                    dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          CH                                                                   dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-ethyl-1,3-                                                                           CH                                                                   dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                        N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                        CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O F      CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O F      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O I      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.3                                                                   cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dithiolan-                                                                         CH                                                                   2-yl                                              1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dithiolan-                                                                         N                                                                    2-yl                                              1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-oxathiolan-                                                                        N                                                                    2-yl                                              1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  S OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  S OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                        --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N  147-165                               --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --CH(OCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH 156-158                               --CH(OCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N  135-139                               --CH(OCH.sub.3).sub.2                                                                     H   H  O Cl     OCH.sub.3                                                                              CH 151-154                               --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N  120-126                               --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH 141-144                               --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH 148-152                               --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O Cl     OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --CH(SCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O Cl     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O Br     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O Cl     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O Br     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-oxathiolan-2-yl                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             CH.sub.3 N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             CH.sub.3 N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       imidazolinyl                                                                  1,3-dioxolan-2-yl                                                                         5-CH.sub.3                                                                        H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolsn-2-yl                                                                         5-CH.sub.3                                                                        H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         5-CH.sub.3                                                                        H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         4-CH.sub.3                                                                        H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         4-CH.sub.3                                                                        H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         4-CH.sub.3                                                                        H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.3 ).sub.3                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Br     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             H        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            H        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub. 2 CH.sub.3                                                                  NHCH.sub.3                                                                             N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                            --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OC.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       2-methoxy-1,3-                                                                            H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Br     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             H        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            H        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H    CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                            --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OCH.sub.3)(OCH.sub.2 H.sub.5).sub.2                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       2-ethoxy-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub. 3                                                   H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C( -n-C.sub.3 H.sub.7)(OCH.sub.3).sub.2                                                 H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       2-ethyl-1,3-                                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O OCH.sub. 3                                                                           OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            C.tbd.CH CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CF.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.2 F                                                                           OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            H        CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                       C(OCH.sub.3).sub.3                                                                        H   H  O F      OCH.sub.3                                                                              CH                                       C(OCH.sub.3).sub.3                                                                        H   H  O I      OCH.sub.3                                                                              CH                                       C(OCH.sub.3).sub.3                                                                        H   H  O OCH.sub.3                                                                            C.tbd.CH CH                                       __________________________________________________________________________

                                      TABLE Ia                                    __________________________________________________________________________    GENERAL STRUCTURE Ia                                                          R.sub.1     R.sub.12                                                                          R  W X      Y        Z  m.p. °C.                       __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CHF.sub.2                                                                  CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                      N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(CH.sub.3)OCH.sub.3                                                                   N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             SCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.2 CH.sub.3                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             i-C.sub.3 H.sub.7                                                                      CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          N                                                                    dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          CH                                                                   dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            4-ethyl-1,3-                                                                           CH                                                                   dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                        N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                        CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O F      CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O F      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O I      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.3                                                                   cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-oxathiolan-2-yl                                                                    N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  S OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         H   H  S OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                        --CH(OCH.sub.3 ).sub.2                                                                    H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --CH(OCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --CH(OCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --CH(OCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --CH(OCH.sub.3).sub.2                                                                     H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H   H  O Cl     OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --CH(OC.sub.2 H.sub.5).sub.2                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --CH(SCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --CH(SCH.sub.3).sub.2                                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O Cl     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O Br     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O Cl     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O Br     OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-oxathiolan-2-yl                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             CH.sub.3 N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             CH.sub.3 N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             CH.sub.3 N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       imidazolinyl                                                                  1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                          H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                          H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                          H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Br     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             H        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            H        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CF.sub.2 H                                                                           OCH.sub. 3                                                                             N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                            --C(OCH.sub.3).sub.3                                                                      H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Br     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             H        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            H        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                       --C(OC.sub.2 H.sub.5).sub. 3                                                              H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                            --C(OC.sub.2 H.sub. 5).sub.3                                                              H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3 ).sub.2                                                    H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C( -n-C.sub.3 H.sub.7)(OCH.sub.3).sub.2                                                 H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       2-ethyl-1,3-                                                                              H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-dioxolan-2-yl                                                                         C.sub.2 H.sub.5                                                                   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         Cl  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       __________________________________________________________________________

                                      TABLE Ib                                    __________________________________________________________________________    GENERAL STRUCTURE Ib                                                          R.sub.1     R.sub.12                                                                         R  W X      Y        Z  m.p. °C.                        __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CHF.sub.2                                                                  CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CF.sub.3                                                                   CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             NHCH.sub.3                                                                             N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                      N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            N(CH.sub.3)OCH.sub.3                                                                   N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             SCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.2 CH.sub.3                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             i-C.sub.3 H.sub.7                                                                      CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                    N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          N                                                                    dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-methyl-1,3-                                                                          CH                                                                   dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            4-ethyl-1,3-                                                                           CH                                                                   dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxol-2-yl                                                                        N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxol-2-yl                                                                        CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     OCF.sub.2 H                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O F      CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O F      OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O I      OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.3                                                                   cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                 cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH(SCH.sub.3).sub.2                                                                    CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-oxathiolan-2-yl                                                                    N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O Cl     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  S CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  S CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  S OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         H  H  S OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                         --CH(OCH.sub.3 ).sub.2                                                                    H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(OCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --CH(OCH.sub.3).sub.2                                                                     H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                            H  H  O Cl     OCH.sub.3                                                                              CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --CH(SCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --CH(SCH.sub.3).sub.2                                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O Cl     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O Br     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O Cl     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O Br     OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             CH.sub.3 N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-oxathiolan-2-yl                                                                       H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                         2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             CH.sub.3 N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             CH.sub.3 N                                         dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             CH.sub.3 N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        imidazolinyl                                                                  1,3-dimethyl-2-                                                                           H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        imidazolinyl                                                                  1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Br     OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             H        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            H        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CF.sub.2 H                                                                           OCH.sub. 3                                                                             N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                             --C(OCH.sub.3).sub.3                                                                      H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Br     OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             H        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            H        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              CH                                        --C(OC.sub.2 H.sub.5).sub. 3                                                              H  H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Cl     OC.sub.2 H.sub.5                                                                       CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                             N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCF.sub.2 H                                                                          CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CF.sub.2 H                                                                           OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                             --C(OC.sub.2 H.sub. 5).sub.3                                                              H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.3 N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3 ).sub.2                                                    H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C( -n-C.sub.3 H.sub.7)(OCH.sub.3).sub.2                                                 H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        2-ethyl-1,3-                                                                              H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-propyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 __________________________________________________________________________

                                      TABLE Ic                                    __________________________________________________________________________    GENERAL STRUCTURE Ic                                                          R.sub.1     R.sub.12                                                                          R  W X      Y        Z  m.p. °C.                       __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                 OC.sub.2 H.sub.5                                                                       N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CHF.sub.2                                                                  OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   N(CH.sub.3).sub.2                                                                      N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              N                                        1,3-dioxolan-2-yl                                                                         H   H  O CF.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O I      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O Br     OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O F      OCH.sub.3                                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            NHCH.sub.3                                                                             CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                   N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                        1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                       1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                        1,3-dioxolan-2-yl                                                                         H   H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              CH                                       1,3-dioxolan-2-yl                                                                         H   H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              N                                        1,3-dioxolan-2-yl                                                                         4-CH.sub.3                                                                        H  O OCH.sub.3                                                                            CH.sub.3 N                                        1,3-dioxolan-2-yl                                                                         4-C.sub.2 H.sub.5                                                                 H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         4-Cl                                                                              H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dioxolan-2-yl                                                                         H   H  S CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O Cl     OCH.sub.3                                                                              CH                                       1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        1,3-dithiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(OCH.sub.3).sub.2                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(OCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        CH(SCH.sub.3).sub.2                                                                       H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O Cl     OCH.sub.3                                                                              CH                                       CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        CH(SCH.sub.3).sub.2                                                                       H   H  O OCH.sub.3                                                                            CH.sub.3 N                                        C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       C(CH.sub.3)(OCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        C(CH.sub.3)(SCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       C(CH.sub.3)(SCH.sub.3).sub.2                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       1,3-oxathiolan-2-yl                                                                       H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       imidazolidinyl                                                                1,3-dimethyl-2-                                                                           H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        imidazolidinyl                                                                --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.3).sub.3                                                                      H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.3).sub.3                                                                      H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       -- C(OC.sub.2 H.sub.5).sub.3                                                              H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             CH.sub.3 CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O Cl     OCH.sub.3                                                                              CH                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H   H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                        __________________________________________________________________________

                                      TABLE Id                                    __________________________________________________________________________    GENERAL STRUCTURE Id                                                          R.sub.1     R.sub.12                                                                         R  W X      Y        Z  m.p. °C.                        __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                 OC.sub.2 H.sub.5                                                                       N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CHF.sub.2                                                                  OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CF.sub.3                                                                   N(CH.sub.3).sub.2                                                                      N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                         H  H  O CF.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O I      OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O Br     OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O F      OCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            NHCH.sub.3                                                                             CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                   N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            cyclopropyl                                                                            N                                         1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                        1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                         1,3-dioxolan-2-yl                                                                         H  H  O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              CH                                        1,3-dioxolan-2-yl                                                                         H  H  O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              N                                         1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                         C.sub.2 H.sub.5                                                                  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         Cl H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                         H  H  S CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        1,3-dithiolan-2-yl                                                                        H  H  O Cl     OCH.sub.3                                                                              CH                                        1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         1,3-dithiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                            CH.sub.3 N                                         CH(OCH.sub.3).sub.2                                                                       H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        CH(OCH.sub.3).sub.2                                                                       H  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        CH(OCH.sub.3).sub.2                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        CH(OCH.sub.3).sub.2                                                                       H  H  O Cl     OCH.sub.3                                                                              CH                                        CH(OCH.sub.3).sub.2                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         CH(OCH.sub.3).sub.2                                                                       H  H  O OCH.sub.3                                                                            CH.sub.3 N                                         CH(OC.sub.2 H.sub.5).sub.2                                                                H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H  H  O Cl     OCH.sub.3                                                                              CH                                        CH(OC.sub.2 H.sub.5).sub.2                                                                H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         CH(OC.sub.2 H.sub.5).sub.2                                                                H  H  O OCH.sub.3                                                                            CH.sub.3 N                                         CH(SCH.sub.3).sub.2                                                                       H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        CH(SCH.sub.3).sub.2                                                                       H  H  O OCH.sub.3                                                                            CH.sub.3 CH                                        CH(SCH.sub.3).sub.2                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        CH(SCH.sub.3).sub.2                                                                       H  H  O Cl     OCH.sub.3                                                                              CH                                        CH(SCH.sub.3).sub.2                                                                       H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         CH(SCH.sub.3).sub.2                                                                       H  H  O OCH.sub.3                                                                            CH.sub.3 N                                         C(CH.sub.3)(OCH.sub.3).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        C(CH.sub.3)(OCH.sub.3).sub.2                                                              H  H  O CH.sub.3                                                                             i-C.sub.3 H.sub.7                                                                      CH                                        C(CH.sub.3)(OCH.sub.3).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         C(CH.sub.3)(SCH.sub.3).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        C(CH.sub.3)(SCH.sub.3).sub.2                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        1,3-oxathiolan-2-yl                                                                       H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        imidazolidinyl                                                                1,3-dimethyl-2-                                                                           H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         imidazolidinyl                                                                --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OCH.sub.3).sub.3                                                                      H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                      H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             CH.sub.3 CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O Cl     OCH.sub.3                                                                              CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O CH.sub.3                                                                             OCH.sub.3                                                                              N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                         __________________________________________________________________________

                                      TABLE Ie                                    __________________________________________________________________________    GENERAL STRUCTURE Ie                                                          R.sub.1     R.sub.12                                                                         R W X      Y        Z  m.p. °C.                         __________________________________________________________________________    1,3-dioxolan-2-yl                                                                         H  H O CH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                         H  H O Cl     OCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                         H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                         H  H O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                             N                                          1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.2 CH.sub.2 F                                                                 OC.sub.2 H.sub.5                                                                       N                                          1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.2 CHF.sub.2                                                                  OCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                             N                                          1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.2 CF.sub.3                                                                   N(CH.sub.3).sub.2                                                                      N                                          1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                         H  H O CF.sub.3                                                                             OCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                         H  H O I      OCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                         H  H O Br     OCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                         H  H O F      OCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                         H  H O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       N                                          1,3-dioxolan-2-yl                                                                         H  H O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                         1,3-dioxolan-2-yl                                                                         H  H O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            NHCH.sub.3                                                                             CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                   N                                          1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        N                                          1,3-dioxolan-2-yl                                                                         H  H O CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                           CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            cyclopropyl                                                                            N                                          1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                         1,3-dioxolan-2-yl                                                                         H  H O CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                     N                                          1,3-dioxolan-2-yl                                                                         H  H O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              CH                                         1,3-dioxolan-2-yl                                                                         H  H O OCH.sub.3                                                                            CH.sub.2 OC.sub.2 H.sub.5                                                              N                                          1,3-dioxolan-2-yl                                                                         CH.sub.3                                                                         H O OCH.sub.3                                                                            CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                         C.sub.2 H.sub.5                                                                  H O OCH.sub.3                                                                            CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                         Cl H O OCH.sub.3                                                                            CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                         H  CH.sub.3                                                                        O CH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                         H  H S CH.sub.3                                                                             CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                        H  H O CH.sub.3                                                                             CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                        H  H O OCH.sub.3                                                                            CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                        H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                         1,3-dithiolan-2-yl                                                                        H  H O Cl     OCH.sub.3                                                                              CH                                         1,3-dithiolan-2-yl                                                                        H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                          1,3-dithiolan-2-yl                                                                        H  H O OCH.sub.3                                                                            CH.sub.3 N                                          CH(OCH.sub.3).sub.2                                                                       H  H O CH.sub.3                                                                             CH.sub.3 CH                                         CH(OCH.sub.3).sub.2                                                                       H  H O OCH.sub.3                                                                            CH.sub.3 CH                                         CH(OCH.sub.3).sub.2                                                                       H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                         CH(OCH.sub.3).sub.2                                                                       H  H O Cl     OCH.sub.3                                                                              CH                                         CH(OCH.sub.3).sub.2                                                                       H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                          CH(OCH.sub.3).sub.2                                                                       H  H O OCH.sub.3                                                                            CH.sub.3 N                                          CH(OC.sub.2 H.sub.5).sub.2                                                                H  H O CH.sub.3                                                                             CH.sub.3 CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                H  H O OCH.sub.3                                                                            CH.sub.3 CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                H  H O Cl     OCH.sub.3                                                                              CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                          CH(OC.sub.2 H.sub.5).sub.2                                                                H  H O OCH.sub.3                                                                            CH.sub.3 N                                          CH(SCH.sub.3).sub.2                                                                       H  H O CH.sub.3                                                                             CH.sub.3 CH                                         CH(SCH.sub.3).sub.2                                                                       H  H O OCH.sub.3                                                                            CH.sub.3 CH                                         CH(SCH.sub.3).sub.2                                                                       H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                         CH(SCH.sub.3).sub.2                                                                       H  H O Cl     OCH.sub.3                                                                              CH                                         CH(SCH.sub.3).sub.2                                                                       H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                          CH(SCH.sub.3).sub.2                                                                       H  H O OCH.sub.3                                                                            CH.sub.3 N                                          C(CH.sub.3)(OCH.sub.3).sub.2                                                              H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         C(CH.sub.3)(OCH.sub.3).sub.2                                                              H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          C(CH.sub.3)(SCH.sub.3).sub.2                                                              H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         C(CH.sub.3)(SCH.sub.3).sub.2                                                              H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          2-methyl-1,3-                                                                             H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         dioxolan-2-yl                                                                 2-methyl-1,3-                                                                             H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         dioxolan-2-yl                                                                 4-methyl-1,3-                                                                             H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          dioxolan-2-yl                                                                 1,3-oxathiolan-2-yl                                                                       H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         1,3-oxathiolan-2-yl                                                                       H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          2-methyl-1,3-                                                                             H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         dithiolan-2-yl                                                                2-methyl-1,3-                                                                             H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          dithiolan-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         pyrimidin-2-yl                                                                hexahydro-1,3-dimethyl-                                                                   H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          pyrimidin-2-yl                                                                4,5-dimethyl-1,3-                                                                         H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         dioxolan-2-yl                                                                 4,5-dimethyl-1,3-                                                                         H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         dioxolan-2-yl                                                                 4-ethyl-1,3-                                                                              H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          dioxolan-2-yl                                                                 1,3-dimethyl-2-                                                                           H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         imidazolidinyl                                                                1,3-dimethyl-2-                                                                           H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          imidazolidinyl                                                                --C(OCH.sub.3).sub.3                                                                      H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                         --C(OCH.sub.3).sub.3                                                                      H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         --C(OCH.sub.3).sub.3                                                                      H  H O CH.sub.3                                                                             CH.sub.3 CH                                         --C(OCH.sub.3).sub.3                                                                      H  H O Cl     OCH.sub.3                                                                              CH                                         --C(OCH.sub.3).sub.3                                                                      H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          --C(OCH.sub.3).sub.3                                                                      H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                          --C(OC.sub.2 H.sub.5).sub.3                                                               H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                         -- C(OC.sub.2 H.sub.5).sub.3                                                              H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H O CH.sub.3                                                                             CH.sub.3 CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H O Cl     OCH.sub.3                                                                              CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                               H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          --C(OC.sub.2 H.sub.5).sub.3                                                               H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                          --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H O CH.sub.3                                                                             CH.sub.3 CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H O Cl     OCH.sub.3                                                                              CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H O CH.sub.3                                                                             OCH.sub.3                                                                              N                                          --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                          __________________________________________________________________________

                                      TABLE II                                    __________________________________________________________________________    General Structure II                                                          R.sub.1  R.sub.11                                                                         R  W X      Y     Z  m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                                1,3-dioxolan-2-yl                                                                      C.sub.3 H.sub.7                                                                  H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               __________________________________________________________________________

                                      TABLE IIa                                   __________________________________________________________________________    General Structure IIa                                                         R.sub.1  R.sub.11                                                                         R  W X      Y     Z  m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                                1,3-dioxolan-2-yl                                                                      C.sub.3 H.sub.7                                                                  H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               __________________________________________________________________________

                                      TABLE IIb                                   __________________________________________________________________________    General Structure IIb                                                         R.sub.1  R.sub.11                                                                         R  W X      Y     Z  m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                                1,3-dioxolan-2-yl                                                                      C.sub.3 H.sub.7                                                                  H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               __________________________________________________________________________

                                      TABLE IIc                                   __________________________________________________________________________    General Structure IIc                                                         R.sub.1  R.sub.11                                                                         R  W X      Y     Z  m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                          N                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                  CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  O OCH.sub.3                                                                            cyclo-                                                                              CH                                                                      propyl                                                1,3-dioxolan-2-yl                                                                      C.sub.3 H.sub.7                                                                  H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H  S CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         CH.sub.3                                                                         O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              CH(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O OCH.sub.3                                                                            CH.sub.3                                                                            N                                               1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OCH.sub.3).sub.3                                                                   CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             CH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O Cl     OCH.sub.3                                                                           CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O CH.sub.3                                                                             OCH.sub.3                                                                           N                                               --C(OC.sub.2 H.sub.5).sub.3                                                            CH.sub.3                                                                         H  O OCH.sub.3                                                                            OCH.sub.3                                                                           N                                               __________________________________________________________________________

                                      TABLE III                                   __________________________________________________________________________    General Structure III                                                         R.sub.1   R  W  X      Y      Z  m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  Cl     OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                   CH                                              1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            cyclo- CH                                                                     propyl                                                 1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       H  S  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                         O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  OCH.sub.3                                                                            CH.sub.3                                                                             N                                               CH(OCH.sub.3).sub.2                                                                     H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  Cl     OCH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                      H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              1,3-dithiolan-2-yl                                                                      H  O  OCH.sub.3                                                                            CH.sub.3                                                                             N                                               1,3-dithiolan-2-yl                                                                      H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dithiolan-2-yl                                                                      H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               --C(OCH.sub.3).sub.3                                                                    H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               __________________________________________________________________________

                                      TABLE IIIa                                  __________________________________________________________________________    General Structure IIIa                                                        R.sub.1   R  W  X      Y      Z  m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  Cl     OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                   CH                                              1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            cyclo- CH                                                                     propyl                                                 1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       H  S  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                         O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  OCH.sub.3                                                                            CH.sub.3                                                                             N                                               CH(OCH.sub.3).sub.2                                                                     H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  Cl     OCH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                      H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              1,3-dithiolan-2-yl                                                                      H  O  OCH.sub.3                                                                            CH.sub.3                                                                             N                                               1,3-dithiolan-2-yl                                                                      H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dithiolan-2-yl                                                                      H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               --C(OCH.sub.3).sub.3                                                                    H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               __________________________________________________________________________

                                      TABLE IIIb                                  __________________________________________________________________________    General Structure IIIb                                                        R.sub.1   R  W  X      Y      Z  m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  Cl     OCH.sub.3                                                                            CH                                              1,3-dioxolan-2-yl                                                                       H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.2 CH.sub.2 F                                                                 NHCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.2 CF.sub.3                                                                   NHCH.sub.3                                                                           N                                               1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                   CH                                              1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            cyclo- CH                                                                     propyl                                                 1,3-dioxolan-2-yl                                                                       H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       H  S  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                         O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  OCH.sub.3                                                                            CH.sub.3                                                                             N                                               CH(OCH.sub.3).sub.2                                                                     H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              CH(OCH.sub.3).sub.2                                                                     H  O  Cl     OCH.sub.3                                                                            CH                                              1,3-dithiolan-2-yl                                                                      H  O  OCH.sub.3                                                                            CH.sub.3                                                                             CH                                              1,3-dithiolan-2-yl                                                                      H  O  OCH.sub.3                                                                            CH.sub.3                                                                             N                                               1,3-dithiolan-2-yl                                                                      H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              1,3-dithiolan-2-yl                                                                      H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OCH.sub.3).sub.3                                                                    H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               --C(OCH.sub.3).sub.3                                                                    H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             CH.sub.3                                                                             CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  Cl     OCH.sub.3                                                                            CH                                              --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  CH.sub.3                                                                             OCH.sub.3                                                                            N                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H  O  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                               __________________________________________________________________________

                                      TABLE IV                                    __________________________________________________________________________    General Structure IV                                                          R.sub.1  R.sub.2                                                                         R W W.sub.1                                                                          A                m.p. °C.                            __________________________________________________________________________                         X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                       1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                      H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                      H H O O  A-2                                                                              OCH.sub.3                                                                           O    --                                            1,3-dioxolan-2-yl                                                                      H H O O  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            1,3-dithiolan-2-yl                                                                     H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dithiolan-2-yl                                                                     H H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            1,3-dithiolan-2-yl                                                                     H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dithiolan-2-yl                                                                     H H O O  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            CH(OCH.sub.3).sub.2                                                                    H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-3                                                                              CH.sub.3                                                                            --   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-3                                                                              OCH.sub.3                                                                           --   --                                            1,3-dioxolan-2-yl                                                                      H H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                      H H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                      H H O S  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                             1,3-dioxolan-2-yl                                                                      H H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                      H H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                      1,3-dithiolan-2-yl                                                                     H H O S  A-3                                                                              CH.sub.3                                                                            --   --                                            1,3-dithiolan-2-yl                                                                     H H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      CH(OCH.sub.3).sub.2                                                                    H H O S  A-3                                                                              OCH.sub.3                                                                           --   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OCH.sub. 3).sub.3                                                                    H H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                     H H O O  A-3                                                                              CH.sub.3                                                                            --   --                                            C(OCH.sub.3).sub.3                                                                     H H O O  A-3                                                                              OCH.sub.3                                                                           --   --                                            C(OCH.sub.3).sub.3                                                                     H H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                            C(OCH.sub.3).sub.3                                                                     H H O O  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                     H H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                     H H O O  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                             C(OCH.sub.3).sub.3                                                                     H H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                     H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OC.sub.2 H.sub. 5).sub.3                                                             H H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OC.sub.2 H.sub.5).sub.3                                                              H H O S  A-2                                                                              CH.sub.3                                                                            O    --                                                                 X.sub.2                                                                             Y.sub.3                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            CH.sub.3                                           C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            C.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              C.sub.2 H.sub.5                                                                     OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H H O S  A-5                                                                              CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                          1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                            CH(OCH.sub.3).sub.2                                                                    H H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                                                 X.sub.3                                                  C(OCH.sub.3).sub.3                                                                     H H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            1,3-dioxolan-2-yl                                                                      H H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            CH(OCH.sub.3).sub.2                                                                    H H O O  A-6                                                                              CH.sub.3                                                                            --   --                                                                 X.sub.4                                                                             Y.sub.4                                                                            Z                                             CH(OCH.sub.3).sub.2                                                                    H H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                            CH(OCH.sub.3).sub.2                                                                    H H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                            1,3-dioxolan-2-yl                                                                      H H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                            1,3-dioxolan-2-yl                                                                      H H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                                                 X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                       C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           N                                             C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                           N                                             C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          N                                             C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              Cl    CH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OCH.sub.3                                                                           Cl   CH                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                           N                                             C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                          CH                                            C(OCH.sub.3).sub.3                                                                     H H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                   N                                             C(OCH.sub.3).sub.3                                                                     H H O O  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                            __________________________________________________________________________

                                      TABLE IVa                                   __________________________________________________________________________    General Structure IVa                                                         R.sub.1  R.sub.12                                                                         R W W.sub.1                                                                          A                m.p. °C.                           __________________________________________________________________________                          X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                      1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                           1,3-dioxolan-2-yl                                                                      H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dioxolan-2-yl                                                                      H  H O O  A-2                                                                              OCH.sub.3                                                                           O    --                                           1,3-dioxolan-2-yl                                                                      H  H O O  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                           1,3-dithiolan-2-yl                                                                     H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dithiolan-2-yl                                                                     H  H O S  A-2                                                                              OCH.sub.3                                                                           CH   --                                           1,3-dithiolan-2-yl                                                                     H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dithiolan-2-yl                                                                     H  H O O  A-2                                                                              OCH.sub.3                                                                           CH   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           CH(OCH.sub.3).sub.2                                                                    H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-3                                                                              CH.sub.3                                                                            --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-3                                                                              OCH.sub.3                                                                           --   --                                           1,3-dioxolan-2-yl                                                                      H  H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                     1,3-dioxolan-2-yl                                                                      H  H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                     1,3-dioxolan-2-yl                                                                      H  H O S  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                            1,3-dioxolan-2-yl                                                                      H  H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                     1,3-dioxolan-2-yl                                                                      H  H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                     1,3-dithiolan-2-yl                                                                     H  H O S  A-3                                                                              CH.sub.3                                                                            --   --                                           1,3-dithiolan-2-yl                                                                     H  H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                     CH(OCH.sub.3).sub.2                                                                    H  H O S  A-3                                                                              OCH.sub.3                                                                           --   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                           C(OCH.sub.3).sub. 3                                                                    H  H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                           C(OCH.sub.3).sub.3                                                                     H  H O O  A-3                                                                              CH.sub.3                                                                            --   --                                           C(OCH.sub.3).sub.3                                                                     H  H O O  A-3                                                                              OCH.sub.3                                                                           --   --                                           C(OCH.sub.3).sub.3                                                                     H  H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                           C(OCH.sub.3).sub.3                                                                     H  H O O  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     H  H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     H  H O O  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                            C(OCH.sub.3).sub.3                                                                     H  H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                     C(OCH.sub.3).sub.3                                                                     H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           C(OC.sub.2 H.sub.5).sub. 3                                                             H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                           C(OC.sub.2 H.sub.5).sub.3                                                              H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                                                 X.sub.2                                                                             Y.sub.3                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                  C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                  C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            CH.sub.3                                          C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            C.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.3 H                                       C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                       C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              C.sub.2 H.sub.5                                                                     OCH.sub.3                                         C(OCH.sub.3).sub.3                                                                     H  H O S  A-5                                                                              CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                         C(OCH.sub.3).sub.3                                                                     H  H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                         1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                           CH(OCH.sub.3).sub.2                                                                    H  H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                                                 X.sub.3                                                 C(OCH.sub.3).sub.3                                                                     H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                           CH(OCH.sub.3).sub.2                                                                    H  H O O  A-6                                                                              CH.sub.3                                                                            --   --                                                                 X.sub.4                                                                             Y.sub.4                                                                            Z                                            CH(OCH.sub.3).sub.2                                                                    H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                           CH(OCH.sub.3).sub.2                                                                    H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                           1,3-dioxolan-2-yl                                                                      H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                                                 X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                      C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           N                                            C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                           CH                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                           N                                            C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          N                                            C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              Cl    CH.sub.3                                                                           CH                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OCH.sub.3                                                                           Cl   CH                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.3                                                                           CH                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                           N                                            C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                          CH                                           C(OCH.sub.3).sub.3                                                                     H  H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    OC.sub.2 H.sub.5                                                                   N                                            C(OCH.sub.3).sub.3                                                                     H  H O O  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                           __________________________________________________________________________

                                      TABLE IVb                                   __________________________________________________________________________    General Structure IVb                                                         R.sub.1 R.sub.12                                                                         R W W.sub.1                                                                          A             Y.sub.2                                                                          m.p. °C.                            __________________________________________________________________________                         X.sub.1                                                                             Y.sub.1                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                            1,3-dioxolan-2-yl                                                                     H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                     H  H O O  A-2                                                                              OCH.sub.3                                                                           O    --                                            1,3-dioxolan-2-yl                                                                     H  H O O  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            1,3-dithiolan-2-yl                                                                    H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dithiolan-2-yl                                                                    H  H O S  A-2                                                                              OCH.sub.3                                                                           CH   --                                            1,3-dithiolan-2-yl                                                                    H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dithiolan-2-yl                                                                    H  H O O  A-2                                                                              OCH.sub.3                                                                           CH   --                                            CH(OCH.sub.3).sub.2                                                                   H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            CH(OCH.sub.3).sub.2                                                                   H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-3                                                                              CH.sub.3                                                                            --   --                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-3                                                                              OCH.sub.3                                                                           --   --                                            1,3-dioxolan-2-yl                                                                     H  H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                            1,3-dioxolan-2-yl                                                                     H  H O S  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                     H  H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                     H  H O S  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                             1,3-dioxolan-2-yl                                                                     H  H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                     H  H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                      1,3-dithiolan-2-yl                                                                    H  H O S  A-3                                                                              CH.sub.3                                                                            --   --                                            1,3-dithiolan-2-yl                                                                    H  H O S  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      CH(OCH.sub.3).sub.2                                                                   H  H O S  A-3                                                                              OCH.sub.3                                                                           --                                                 CH(OCH.sub.3).sub.2                                                                   H  H O S  A-4                                                                              OCH.sub.3                                                                           CH.sub.3                                           C(OCH.sub.3).sub.3                                                                    H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-2                                                                              OCH.sub.3                                                                           O    --                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-2                                                                              OCF.sub.2 H                                                                         O    --                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-2                                                                              CH.sub.3                                                                            CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-2                                                                              OCH.sub.3                                                                           CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-2                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                            C(OCH.sub.3).sub.3                                                                    H  H O O  A-3                                                                              CH.sub.3                                                                            --   --                                            C(OCH.sub.3).sub.3                                                                    H  H O O  A-3                                                                              OCH.sub.3                                                                           --   --                                            C(OCH.sub.3).sub.3                                                                    H  H O O  A-3                                                                              OCF.sub.2 H                                                                         --   --                                            C(OCH.sub.3).sub.3                                                                    H  H O O  A-4                                                                              OCH.sub.3                                                                           --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                    H  H O O  A-4                                                                              CH.sub.3                                                                            --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                    H  H O O  A-4                                                                              OC.sub.2 H.sub.5                                                                    --   H                                             C(OCH.sub.3).sub.3                                                                    H  H O O  A-4                                                                              OCF.sub.2 H                                                                         --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                    H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OC.sub.2 H.sub.5).sub.3                                                             H  H O O  A-2                                                                              CH.sub.3                                                                            O    --                                            C(OC.sub.2 H.sub.5).sub.3                                                             H  H O S  A-2                                                                              CH.sub.3                                                                            O    --                                                                 X.sub.2                                                                             Y.sub.3                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                          C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            CH.sub.3                                           C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            C.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              C.sub.2 H.sub.5                                                                     OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                    H  H O S  A-5                                                                              CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                    H  H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                          1,3-dioxolan-                                                                         H  H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub. 3                                                                         --                                            2-yl                                                                          1,3-dioxolan-                                                                         H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                            2-yl                                                                          1,3-dioxolan-                                                                         H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                            2-yl                                                                          1,3-dioxolan-                                                                         H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                            2-yl                                                                          1,3-dioxolan-                                                                         H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                            2-yl                                                                          1,3-dioxolan-                                                                         H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                            2-yl                                                                          CH(OCH.sub.3).sub.2                                                                   H  H O S  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                            CH(OCH.sub.3).sub.2                                                                   H  H O S  A-5                                                                              CH.sub.3                                                                            OC.sub.2 H.sub.5                                                                   --                                            CH(OCH.sub.3).sub.2                                                                   H  H O S  A-5                                                                              CH.sub.3                                                                            SCH.sub.3                                                                          --                                            CH(OCH.sub.3).sub.2                                                                   H  H O S  A-5                                                                              CH.sub.3                                                                            SC.sub.2 H.sub.5                                                                   --                                            CH(OCH.sub.3).sub.2                                                                   H  H O S  A-5                                                                              CH.sub.3                                                                            OCF.sub.2 H                                                                        --                                            CH(OCH.sub.3).sub.2                                                                   H  H O S  A-5                                                                              CH.sub.3                                                                            SCF.sub.2 H                                                                        --                                            CH(OCH.sub.3).sub.2                                                                   H  H O O  A-5                                                                              CH.sub.3                                                                            OCH.sub.3                                                                          --                                                                 X.sub.3                                                  C(OCH.sub.3).sub.3                                                                    H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            1,3-dioxolan-                                                                         H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            2-yl                                                                          1,3-dioxolan-                                                                         H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            2-yl                                                                          CH(OCH.sub.3).sub.2                                                                   H  H O S  A-6                                                                              CH.sub.3                                                                            --   --                                            CH(OCH.sub.3).sub.2                                                                   H  H O S  A-6                                                                              OCH.sub.3                                                                           --   --                                            CH(OCH.sub.3).sub.2                                                                   H  H O O  A-6                                                                              CH.sub.3                                                                            --   --                                                                 X.sub.4                                                                             Y.sub.4                                                                            Z                                             CH(OCH.sub.3).sub.2                                                                   H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                            CH(OCH.sub.3).sub.2                                                                   H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                            1,3-dioxolan-                                                                         H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                            2-yl                                                                          1,3-dioxolan-                                                                         H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                            2-yl                                                                          C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           N                                             C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              OCH.sub. 3                                                                          CH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              OCH.sub.3                                                                           CH.sub.3                                                                           N                                             C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                          N                                             C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              Cl    CH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              OCH.sub.3                                                                           Cl   CH                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    CH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                           N                                             C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                          CH                                            C(OCH.sub.3).sub.3                                                                    H  H O S  A-7                                                                              OC.sub.2 H.sub.5                                                                    OCH.sub.2 H.sub.5                                                                  N                                             C(OCH.sub.3).sub.3                                                                    H  H O O  A-7                                                                              CH.sub.3                                                                            CH.sub.3                                                                           CH                                            __________________________________________________________________________

                                      TABLE V                                     __________________________________________________________________________    General Structure V                                                           __________________________________________________________________________    R.sub.1  R.sub.11                                                                         R W  A   X.sub.1                                                                             Y.sub.1                                                                          Y.sub.2                                                                          m.p. °C.                              __________________________________________________________________________    1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-2 CH.sub.3                                                                            O  --                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-2 OCF.sub.2 H                                                                         O  --                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-2 OCH.sub.3                                                                           O  --                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-2 CH.sub.3                                                                            CH.sub.2                                                                         --                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-2 OCH.sub.3                                                                           CH.sub.2                                                                         --                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-2 OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                         --                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O  A-2 CH.sub.3                                                                            O  --                                              1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O  A-2 OCH.sub.3                                                                           CH.sub.2                                                                         --                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-3 CH.sub.3                                                                            -- --                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-3 OCH.sub.3                                                                           -- --                                              1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-4 CH.sub.3                                                                            -- CH.sub.3                                        1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-4 OCH.sub.3                                                                           -- H                                               1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O  A-4 OCF.sub.2 H                                                                         -- CH.sub.3                                        __________________________________________________________________________    R.sub.1  R.sub.11                                                                         R.sub.12                                                                          R                                                                              W A.sub.1                                                                          X.sub.1                                                                           Y.sub.2                                                                           Y   m.p. °C.                             __________________________________________________________________________    C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O A-2                                                                              CH.sub.3                                                                          O   --                                              C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O A-3                                                                              CH.sub.3                                                                          --  --                                              C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O A-4                                                                              CH.sub.3                                                                          --  CH.sub.3                                                              X.sub.2                                                                           Y.sub.2                                             C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O A-5                                                                              CH.sub.3                                                                          --  OCH.sub.3                                       1,3-dioxolan-                                                                          CH.sub.3                                                                         H  H O A-5                                                                              CH.sub.3                                                                          SCH.sub.3                                                                         --                                              2-yl                                                                                                X.sub.3                                                 C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         H  H O A-6                                                                              CH.sub.3                                                                          --  --                                              C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O A-6                                                                              OCH.sub.3                                                                         --  --                                                                    X.sub.4                                                                           Y.sub.4                                                                           Z                                               1,3-dioxolan-                                                                          CH.sub.3                                                                         H  H O A-7                                                                              CH.sub.3                                                                          CH.sub.3                                                                          CH                                              2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H  H O A-7                                                                              OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                              __________________________________________________________________________

                                      TABLE Va                                    __________________________________________________________________________    General Structure Va                                                          R.sub.1  R.sub.11                                                                         R W A              m.p. °C.                                __________________________________________________________________________                       X.sub.1                                                                            Y.sub.1                                                                           Y.sub.2                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              OCH.sub.3                                                                          --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                          1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCH.sub.3                                                                          --  H                                                 1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.2                                               C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                             1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                             2-yl                                                                                             X.sub.3                                                    C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         H O A-6                                                                              CH.sub.3                                                   C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-6                                                                              OCH.sub.3                                                                     X.sub.4                                                                            Y.sub.4                                                                           Z                                                 1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                          CH                                                2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                __________________________________________________________________________

                                      TABLE Vb                                    __________________________________________________________________________    General Structure Vb                                                          R.sub.1  R.sub.11                                                                         R W A              m.p. °C.                                __________________________________________________________________________                       X.sub.1                                                                            Y.sub.1                                                                           Y.sub.2                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              OCH.sub.3                                                                          --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                          1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCH.sub.3                                                                          --  H                                                 1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.3                                               C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                             1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                             2-yl                                                                                             X.sub.3                                                    C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         H O A-6                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-6                                                                              OCH.sub.3                                                                          --  --                                                                   X.sub.4                                                                            Y.sub.4                                                                           Z                                                 1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                          CH                                                2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                __________________________________________________________________________

                                      TABLE Vc                                    __________________________________________________________________________    General Structure Vc                                                          R.sub.1  R.sub.11                                                                         R W A              m.p. °C.                                __________________________________________________________________________                       X.sub.1                                                                            Y.sub.1                                                                           Y.sub.2                                           1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCF.sub.2 H                                                                        O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          O   --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-2                                                                              OC.sub.2 H.sub.5                                                                   CH.sub.2                                                                          --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                1,3-dithiolan-2-yl                                                                     CH.sub.3                                                                         H O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-3                                                                              OCH.sub.3                                                                          --  --                                                1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                          1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCH.sub.3                                                                          --  H                                                 1,3-dioxolan-2-yl                                                                      CH.sub.3                                                                         H O A-4                                                                              OCF.sub.2 H                                                                        --  CH.sub.3                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-2                                                                              CH.sub.3                                                                           O   --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-3                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                                             X.sub.2                                                                            Y.sub.3                                               C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                             1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                             2-yl                                                                                             X.sub.3                                                    C(CH.sub.3)(OCH.sub.3).sub.2                                                           CH.sub.3                                                                         H O A-6                                                                              CH.sub.3                                                                           --  --                                                C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-6                                                                              OCH.sub.3                                                                          --  --                                                                   X.sub.4                                                                            Y.sub.4                                                                           Z                                                 1,3-dioxolan-                                                                          CH.sub.3                                                                         H O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                          CH                                                2-yl                                                                          C(OCH.sub.3).sub.3                                                                     CH.sub.3                                                                         H O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                __________________________________________________________________________

                  TABLE VI                                                        ______________________________________                                        General Structure VI                                                                                                  m.p.                                  R.sub.1   R      W     A                °C.                            ______________________________________                                                                    X.sub.1                                                                              Y.sub.1                                                                             Y.sub.2                              1,3-dioxolan-2-yl                                                                       H      O     A-2  CH.sub.3                                                                             O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCF.sub.2 H                                                                          O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCH.sub.3                                                                            O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  CH.sub.3                                                                             CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCH.sub.3                                                                            CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                            --                                   1,3-dithiolan-2-yl                                                                      H      O     A-2  CH.sub.3                                                                             O     --                                   1,3-dithiolan-2-yl                                                                      H      O     A-2  OCH.sub.3                                                                            CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-3  CH.sub.3                                                                             --    --                                   1,3-dioxolan-2-yl                                                                       H      O     A-3  OCH.sub.3                                                                            --    --                                   1,3-dioxolan-2-yl                                                                       H      O     A-4  CH.sub.3                                                                             --    CH.sub.3                             1,3-dioxolan-2-yl                                                                       H      O     A-4  OCH.sub.3                                                                            --    H                                    1,3-d1oxolan-2-yl                                                                       H      O     A-4  OCF.sub.2 H                                                                          --    CH.sub.3                             C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-2  CH     O.sub.3                                                                             --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-3  CH.sub.3                                                                             --    --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-4  CH.sub.3                                                                             --    CH.sub.3                                                         X.sub.2                                                                              Y.sub.3                                    C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-5  CH.sub.3                                                                             OCH.sub.3                                  1,3-dioxolan-                                                                           CH.sub.3                                                                             O     A-5  CH.sub.3                                                                             SCH.sub.3                                  2-yl                                                                                                      X.sub.3                                           C(CH.sub.3)(OCH.sub.3).sub.2                                                            CH.sub.3                                                                             O     A-6  CH.sub.3                                                                             --    --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-6  OCH    --.sub.3                                                                            --                                                               X.sub.4                                                                              Y.sub.4                                                                             Z                                    1,3-dioxoan-                                                                            CH.sub.3                                                                             O     A-7  CH     CH.sub.3                                                                            CH.sub.3                             2-yl                                                                          C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-7  OCH    OCH.sub.3                                                                           CH.sub.3                             ______________________________________                                    

                  TABLE VIa                                                       ______________________________________                                        General Structure VIa                                                                                                 m.p.                                  R.sub.1   R      W     A                °C.                            ______________________________________                                                                    X.sub.1                                                                              Y.sub.1                                                                             Y.sub.2                              1,3-dioxolan-2-yl                                                                       H      O     A-2  CH.sub.3                                                                             O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCF.sub.2 H                                                                          O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCH.sub.3                                                                            O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  CH.sub.3                                                                             CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCH.sub.3                                                                            CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                            --                                   1,3-dithiolan-2-yl                                                                      H      O     A-2  CH.sub.3                                                                             O     --                                   1,3-dithiolan-2-yl                                                                      H      O     A-2  OCH.sub.3                                                                            CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-3  CH.sub.3                                                                             --    --                                   1,3-dioxolan-2-yl                                                                       H      O     A-3  OCH.sub.3                                                                            --    --                                   1,3-dioxolan-2-yl                                                                       H      O     A-4  CH.sub.3                                                                             --    CH.sub.3                             1,3-dioxolan-2-yl                                                                       H      O     A-4  OCH.sub.3                                                                            --    H                                    1,3-dioxolan-2-yl                                                                       H      O     A-4  OCF.sub.2 H                                                                          --    CH.sub.3                             C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-2  CH.sub.3                                                                             O     --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-3  CH.sub.3                                                                             --    --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-4  CH.sub.3                                                                             --    CH.sub.3                                                         X.sub.2                                                                              Y.sub.3                                    C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-5  CH.sub.3                                                                             OCH.sub.3                                  1,3-dioxolan-                                                                           CH.sub.3                                                                             O     A-5  CH.sub.3                                                                             SCH.sub.3                                  2-yl                                                                                                      X.sub.3                                           C(CH.sub.3)(OCH.sub.3).sub.2                                                            CH.sub.3                                                                             O     A-6  CH.sub.3                                                                             --    --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-6  OCH.sub.3                                                                            --    --                                                               X.sub.4                                                                              Y.sub.4                                                                             Z                                    1,3-dioxolan-                                                                           CH.sub.3                                                                             O     A-7  CH.sub.3                                                                             CH.sub.3                                                                            CH                                   2-yl                                                                          C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-7  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                   ______________________________________                                    

                  TABLE VIb                                                       ______________________________________                                        General Structure VIb                                                                                                 m.p.                                  R.sub.1   R      W     A                °C.                            ______________________________________                                                                    X.sub.1                                                                              Y.sub.1                                                                             Y.sub.2                              1,3-dioxolan-2-yl                                                                       H      O     A-2  CH.sub.3                                                                             O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCF.sub.2 H                                                                          O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCH.sub.3                                                                            O     --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  CH.sub.3                                                                             CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OCH.sub.3                                                                            CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-2  OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                            --                                   1,3-dithiolan-2-yl                                                                      H      O     A-2  CH.sub.3                                                                             O     --                                   1,3-dithiolan-2-yl                                                                      H      O     A-2  OCH.sub.3                                                                            CH.sub.2                                                                            --                                   1,3-dioxolan-2-yl                                                                       H      O     A-3  CH.sub.3                                                                             --    --                                   1,3-dioxolan-2-yl                                                                       H      O     A-3  OCH.sub.3                                                                            --    --                                   1,3-dioxolan-2-yl                                                                       H      O     A-4  CH.sub.3                                                                             --    CH.sub.3                             1,3-dioxolan-2-yl                                                                       H      O     A-4  OCH.sub.3                                                                            --    H                                    1,3-dioxolan-2-yl                                                                       H      O     A-4  OCF.sub.2 H                                                                          --    CH.sub.3                             C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-2  CH.sub.3                                                                             O     --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-3  CH.sub.3                                                                             --    --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-4  CH.sub.3                                                                             --    CH.sub.3                                                         X.sub.2                                                                              Y.sub.3                                    C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-5  CH.sub.3                                                                             OCH.sub.3                                  1,3-dioxolan-                                                                           CH.sub.3                                                                             O     A-5  CH.sub.3                                                                             SCH.sub.3                                  2-yl                                                                                                      X.sub.3                                           C(CH.sub.3)(OCH.sub.3).sub.2                                                            CH.sub.3                                                                             O     A-6  CH.sub.3                                                                             --    --                                   C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-6  OCH.sub.3                                                                            --    --                                                               X.sub.4                                                                              Y.sub.4                                                                             Z                                    1,3-dioxolan-                                                                           CH.sub.3                                                                             O     A-7  CH.sub.3                                                                             CH.sub.3                                                                            CH                                   2-yl                                                                          C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                             O     A-7  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                   ______________________________________                                    

                                      TABLE VII                                   __________________________________________________________________________    General Structure VII                                                         R.sub.1   R  R.sub.14                                                                           E  W X      Y        Z  m.p. °C.                     __________________________________________________________________________    C(OCH.sub.3).sub.3                                                                      H  H    -- CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3 CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O Cl     OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O Br     OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             H        CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            H        CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            CH.sub.2 Ohd 2H.sub.5                                                                  CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCF.sub.2 H                                                                          OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                    CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                       CH                                     C(OCH.sub. 3).sub.3                                                                     H  H    -- O CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                     CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                     CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                        CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OC.sub.2 H.sub.5                                                                     OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCF.sub.2 H                                                                          OCF.sub.2 H                                                                            CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.2 F                                                                           OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.2 Cl                                                                          OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CF.sub.3                                                                             OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O Cl     CH                                              C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.2 H.sub.5                                                                    OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.2 CF.sub.3                                                                   OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             CH.sub.3 N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            cyclo-   N                                                                    propyl                                          C(OCH.sub.3).sub.3                                                                      H  H    -- O OC.sub.2 H.sub.5                                                                     NHCH.sub.3                                                                             N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH    OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH    CH.sub.3 N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH    OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- S OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  3-F  -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  5-Cl -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  5-CH.sub.3                                                                         -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  5-C.sub.2 H.sub.5                                                                  -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  6-OCH.sub.3                                                                        -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  6-OC.sub.2 H.sub.5                                                                 -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  6-SCH.sub.3                                                                        -- O OCH.sub. 3                                                                           OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  6-SC.sub.2 H.sub.5                                                                 -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  5-Br -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O Cl     OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                      C(OC.sub.2 H.sub.5).sub.3                                                               H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O CH.sub.3                                                                             CH.sub.3 CH                                     C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O Cl     OCH.sub.3                                                                              CH                                     C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O CH.sub.3                                                                             OCH.sub.3                                                                              N                                      C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                         H    CH.sub.2                                                                         O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OCH.sub.3).sub.3                                                                      H  H    CH.sub.2                                                                         O OCH.sub.2 CHF.sub.2                                                                  CH.sub.3 N                                      C(OCH.sub.3).sub.3                                                                      H  H    CH.sub.2                                                                         O CH.sub.3                                                                              .sub.-i-C.sub.3 H.sub.7                                                               CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                   N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             N(CH.sub.2).sub.3                                                                      N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            CF.sub.3 CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             SCH.sub.3                                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                              N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             OCH.sub.2 CH.tbd.CH                                                                    N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O CH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                     N                                      C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            SCF.sub.2 H                                                                            CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            1,3-dioxolan-2-yl                                                                      CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            4 methyl-1,3-                                                                          N                                                                    dioxolan-2-yl                                   C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            4-ethyl-1,3-                                                                           CH                                                                   dioxolan-2-yl                                   C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                     CH                                     C(OCH.sub.3).sub.3                                                                      H  H    -- O OCH.sub.3                                                                            1,3-oxathiolan-2-yl                                                                    N                                      C(OCH.sub.3)(OC.sub.2 H.sub.5).sub.2                                                    H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     C(OC.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                    H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     2-methoxy-1,3-                                                                          H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     dioxolan-2-yl                                                                 2-ethoxy-1,3-                                                                           H  H    -- O OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     dioxolan-2-yl                                                                 __________________________________________________________________________

                                      TABLE VIIa                                  __________________________________________________________________________    General Structure VIIa                                                        R.sub.1   R R.sub.14                                                                         E W A              m.p. °C.                             __________________________________________________________________________                          X.sub.1                                                                            Y.sub.1                                                                           Y.sub.2                                        C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-2                                                                              CH.sub.3                                                                           O   --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-2                                                                              OCH.sub.3                                                                          O   --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-2                                                                              OCH.sub.3                                                                          CH.sub.2                                                                          --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-2                                                                              OCF.sub.2 H                                                                        O   --                                             C(OC.sub.2 H.sub.5).sub.3                                                               H H  --                                                                              O A-2                                                                              CH.sub.3                                                                           O   --                                             C(OC.sub.2 H.sub.5).sub.3                                                               H H  --                                                                              O A-2                                                                              OCH.sub.3                                                                          O   --                                             C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H H  --                                                                              O A-2                                                                              CH.sub.3                                                                           O   --                                             C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H H  --                                                                              O A-2                                                                              OCH.sub.3                                                                          O   --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-3                                                                              CH.sub.3                                                                           --  --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-3                                                                              OCH.sub.3                                                                          --  --                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-4                                                                              CH.sub.3                                                                           --  CH.sub.3                                       C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-4                                                                              OCH.sub.3                                                                          --  CH.sub.3                                       C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-4                                                                              OCH.sub.3                                                                          --  H                                                                    X.sub.2                                                                            Y.sub.3                                            C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-5                                                                              CH.sub.3                                                                           OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-5                                                                              CH.sub.3                                                                           SCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-5                                                                              CH.sub.3                                                                           CH.sub.3                                                                 X.sub.3                                                 C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-6                                                                              CH.sub.3                                                C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-6                                                                              OCH.sub.3                                                                     X.sub.4                                                                            Y.sub.4                                                                           Z                                              C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-7                                                                              CH.sub.3                                                                           CH.sub.3                                                                          CH                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                             C(OCH.sub.3).sub.3                                                                      H H  --                                                                              O A-7                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                         N                                              __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared inconventional ways. They include dusts, granules, pellets, solutions,suspensions, emulsions, wettable powders, emulsifiable concentrates andthe like. Many of these may be applied directly. Sprayable formulationscan be extended in suitable media and used at spray volumes of from afew liters to several hundred liters per hectare. High strengthcompositions are primarily used as intermediates for furtherformulation. The formulations, broadly, contain about 1% to 99% byweight of active ingredient(s) and at least one of (a) about 0.1% to 20%surfactant(s) and (b) about 5% to 99% solid or liquid diluent(s). Morespecifically, they will contain these ingredients in the followingapproximate proportions:

    ______________________________________                                                    Active  Weight Percent*                                                       Ingredient                                                                            Diluent(s)                                                                              Surfactant(s)                                   ______________________________________                                        Wettable Powders                                                                            20-90      0-74     1-10                                        Oil Suspensions,                                                                             5-50     40-95     0-15                                        Emulsions, Solutions,                                                         (including Emulsifiable                                                       Concentrates)                                                                 Aqueous Suspension                                                                          10-50     40-84     1-20                                        Dusts          1-25     70-99     0-5                                         Granules and Pellets                                                                         1-95      5-99     0-15                                        High Strength 90-99      0-10     0-2                                         Compositions                                                                  ______________________________________                                         *Active ingredient plus at least one of a Surfactant or a Diluent equals      100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J. The more absorptive diluents are preferred for wettablepowders and the denser ones for dusts. Typical liquid diluents andsolvents are described in Marsden, "Solvents Guide," 2nd Ed.,Interscience, New York, 1950. Solubility under 0.1% is preferred forsuspension concentrates; solution concentrates are preferably stableagainst phase separation at 0° C. "McCutcheon's Detergents andEmulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well asSisely and Wood, "Encyclopedia of Surface Active Agents", ChemicalPublishing Co., Inc., New York, 1964, list surfactants and recommendeduses. All formulations can contain minor amounts of additives to reducefoaming, caking, corrosion, microbiological growth, etc. Preferably,ingredients should be approved by the U.S. Environmental ProtectionAgency for the use intended.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example,Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made byspraying the active material upon preformed granular carriers or byagglomeration techniques.

In the following examples, all parts are by weight unless otherwiseindicated.

EXAMPLE 5 Wettable Powder

    ______________________________________                                        3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                                          80%                                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                sulfonamide                                                                   sodium alkylnaphthalenesulfonate                                                                        2%                                                  sodium ligninsulfonate    2%                                                  synthetic amorphous silica                                                                              3%                                                  kaolinite                 13%                                                 ______________________________________                                    

The ingredients are blended, hammer-milled until all the solids areessentially under 50 microns, reblended, and packaged.

EXAMPLE 6 Wettable Powder

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                       50%                                                (1,3-dioxolan-2-yl)-2-thiophenesulfonamide                                    sodium alkylnaphthalenesulfonate                                                                          2%                                                low viscosity methyl cellulose                                                                            2%                                                diatomaceous earth         36%                                                ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milledto produce particles essentially all below 10 microns in diameter. Theproduct is reblended before packaging.

EXAMPLE 7 High Strength Concentrate

    ______________________________________                                        3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                                           99%                                                1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                sulfonamide                                                                   silica aerogel            0.5%                                                synthetic amorphous silica                                                                              0.5%                                                ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce amaterial essentially all passing a U.S.S. No. 50 screen (0.3 mmopening). The concentrate may be formulated further if necessary.

EXAMPLE 8 Wettable Powder

    ______________________________________                                        3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                                          20%                                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                sulfonamide                                                                   sodium alkylnaphthalenesulfonate                                                                        4%                                                  sodium ligninsulfonate    4%                                                  low viscosity methyl cellulose                                                                          3%                                                  attapulgite               69%                                                 ______________________________________                                    

The ingredients are thoroughly blended. After grinding in a hammer-millto produce particles essentially all below 100 microns, the material isreblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) andpackaged.

EXAMPLE 9 Oil Suspension

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                       25%                                                (1,3-dioxolan-2-yl)-2-thiophenesulfonamide                                    polyoxyethylene sorbitol hexaoleate                                                                       5%                                                highly aliphatic hydrocarbon oil                                                                         70%                                                ______________________________________                                    

The ingredients are ground together in a sand mill until the solidparticles have been reduced to under about 5 microns. The resultingthick suspension may be applied directly, but preferably after beingextended with oils or emulsified in water.

EXAMPLE 10 Oil Suspension

    ______________________________________                                        3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                                          35%                                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                sulfonamide                                                                   blend of polyalcohol carboxylic                                                                          6%                                                 esters and oil soluble petroleum                                              sulfonates                                                                    xylene                    59%                                                 ______________________________________                                    

The ingredients are combined and ground together in a sand mill toproduce particles essentially all below 5 microns. The product can beused directly, extended with oils, or emulsified in water.

EXAMPLE 11 Aqueous Suspension

    ______________________________________                                        3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                                           40%                                                1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                sulfonamide                                                                   polyacrylic acid thickener 0.3%                                               dodecylphenol polyethylene 0.5%                                               glycol ether                                                                  disodium phosphate         1%                                                 monosodium phosphate       0.5%                                               polyvinyl alcohol          1.0%                                               water                      56.7%                                              ______________________________________                                    

The ingredients are blended and ground together in a sand mill toproduce particles essentially all under 5 microns in size.

EXAMPLE 12 Solution

    ______________________________________                                        3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                                          30%                                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                sulfonamide                                                                   dimethylformamide         70%                                                 ______________________________________                                    

The ingredients are combined and stirred to produce a solution, whichcan be used for low volume applications.

EXAMPLE 13 Dust

    ______________________________________                                        wettable powder of Example 6                                                                       10%                                                      Pyrophyllite (powder)                                                                              90%                                                      ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blendedand then packaged. The product is suitable for use a a dust.

EXAMPLE 14 Low Strength Granule

    ______________________________________                                        3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                                           0.1%                                               1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                sulfonamide                                                                   attapulgite granules      99.9%                                               (U.S.S. 20-40 mesh)                                                           ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution issprayed upon dedusted granules in a double cone blender. After sprayingof the solution has been completed, the material is warmed to evaporatethe solvent. The material is allowed to cool and then packaged.

EXAMPLE 15 Granule

    ______________________________________                                        Wettable Powder of Example 6                                                                          5%                                                    attapulgite granules   95%                                                    (U.S.S. 20-40 mesh: 0.84-0.42 mm)                                             ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on thesurface of attapulgite granules in a double-cone blender. The granulesare dried and packaged.

EXAMPLE 16 Granule

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                       80%                                                (1,3-dioxolan-2-yl)-2-thiophenesulfonamide                                    wetting agent               1%                                                crude ligninsulfonate salt (containing                                                                   10%                                                5-20% of the natural sugars)                                                  attapulgite clay            9%                                                ______________________________________                                    

The ingredients are blended and milled to pass through a 100 meshscreen. This material is then added to a fluid bed granulator, the airflow is adjusted to gently fluidize the material, and a fine spray ofwater is sprayed onto the fluidized material. The fluidization andspraying are continued until granules of the desired size range aremade. The spraying is stopped, but fluidization is continued, optionallywith heat, until the water content is reduced to the desired level,generally less than 1%. The material is then discharged, screened to thedesired size range, generally 14-100 mesh (1410-149 microns), andpackaged for use.

EXAMPLE 17 Extruded Pellet

    ______________________________________                                        3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                                          25%                                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                sulfonamide                                                                   anhydrous sodium sulfate  10%                                                 crude calcium ligninsulfonate                                                                            5%                                                 sodium alkylnaphthalenesulfonate                                                                         1%                                                 calcium/magnesium bentonite                                                                             59%                                                 ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about12% water. The mixture is extruded as cylinders about 3 mm diameterwhich are cut to produce pellets about 3 mm long. These may be useddirectly after drying, or the dried pellets may be crushed to pass aU.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S.No. 40 sieve (0.42 mm openings) may be packaged for use and the finesrecycled.

Utility

Test results indicate that the compounds of the present invention areactive herbicides. They have utility for broad-spectrum pre- and/orpost-emergence weed control in areas where complete control of allvegetation is desired, such as around fuel storage tanks, ammunitiondepots, industrial storage areas, parking lots, drive-in theaters,around billboards, highway and railroad structures. Alternatively, thesubject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention aredetermined by a number of factors, including their use as plant growthmodifiers or as herbicides, the crop species involved, the types ofweeds to be controlled, weather and climate, formulations selected, modeof application, amount of foliage present, etc. In general terms, thesubject compounds should be applied at levels of around 0.01 to 5.0kg/ha, the lower rates being suggested for use on lighter soils and/orthose having a low organic matter content, for plant growth modificationor for situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any othercommercial herbicide; examples of which are those of the triazine,triazole, uracil, urea, amide, diphenylether, carbamate and bipyridyliumtypes.

The herbicidal properties of the subject compounds were discovered in anumber of greenhouse tests. The test procedures and results follow.##STR54##

Test A

Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloacrusgalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia),morningglory (Ipomoea spp.), cocklebur (Xanthium pensylvanicum),sorghum, corn, soybean, sugar beet, cotton, rice, wheat and purplenutsedge (Cyperus rotundus) tubers were planted and treatedpre-emergence with the test chemicals dissolved in a non-phytotoxicsolvent. At the same time, these crop and weed species were treated witha soil/foliage application. At the time of treatment, the plants rangedin height from 2 to 18 cm. Treated plants and controls were maintainedin a greenhouse for sixteen days, after which all species were comparedto controls and visually rated for response to treatment. The ratings,summarized in Table A, are based on a numerical scale extending from0=no injury, to 10=complete kill. The accompanying descriptive symbolshave the following meanings:

C=chlorosis or necrosis;

B=burn

D=defoliation

E=emergence inhibition;

G=growth retardation; and

H=formative effects.

U=unusual pigmentation

X=axillary stimulation

S=albinism

6Y=abscised buds or flowers.

                                      TABLE A                                     __________________________________________________________________________             Compound                                                                            Compound                                                                            Compound                                                                            Compound                                                                            Compound                                                                            Compound                                                                            Compound                                                                            Compound                                                                            Compound                      1     2     3     4     5     6     7     8     9                    Rate kg/ha                                                                             0.05  0.05  0.05  0.05  0.05  0.05  0.05  0.05  0.05                 __________________________________________________________________________    POST-EMERGENCE                                                                Morningglory                                                                           9C    10C   10C   10C   10C   10C   6C,9G 9C    10C                  Cocklebur                                                                              9C    10C   4C,9H 9C    9H    9C    9C    10C   9C                   Sicklepod                                                                              2C,5G 7G                                                             Velvetleaf           9C    9C    2C,7G 9C    6C,9G 10C   9C                   Nutsedge 4G    10C   9C    8C    4G    9C    6G    3G    4C,8G                Crabgrass                                                                              3C,8G 5C,9G 7H    7G    2G    2C,6G 5G    4G    0                    Barnyardgrass                                                                          5C,9H 9C    9C    9C    9C    3C,9H 4C,9H 4C,9H 8H                   Cheatgrass           10C   6C,9G 0     3C,8G 0     2C,3H 0                    Wild Oats                                                                              8G    5C,9G 2C,5G 2G    0     0     0     0     0                    Wheat    5G    6C,9G 2G    2G    0     0     0     0     0                    Corn     2C,9G 3C,9G 7U,9C 10C   7U,9C 2C,8H 2C,9G 5C,9G 1H                   Soybean  9C    9C    9C    9C    5C,9G 5C,9G 5C,9G 5C,9G 3H,9G,7X             Rice     9C    9C    9C    9C    4C,8G 4C,9G 7G    5G    6G                   Sorghum  9G    5C,9G 5C,9H 2U,8H 3C,9H 4C,9H 3C,9H 5C,9H 9H                   Sugar beet                                                                             10C   9C    9C    9C    9C    9C    3C,9G 9C    9C                   Cotton   9C    9C    9C    9C    5C,9G 9C    9C    9C    9C                   PRE-EMERGENCE                                                                 Morningglory                                                                           9G    4C,9G 9C    9G    9G    9H    8H    8G    8G                   Cocklebur                                                                              8H    9H    7H    8H    3H    8H    9H    5G    7G                   Sicklepod                                                                              9G    9G                                                             Velvetleaf           10C   9C    5G    9G    4C,8G 3C,8G 4G                   Nutsedge 0     10E   10E   10E   3G    2C,9G 0     3G    3G                   Crabgrass                                                                              2C,5G 7G    2C,7G 4C,9G 2G    0     0     0     0                    Barnyardgrass                                                                          3C,7H 9H    9H    9H    3C,7G 4C,9H 0     3C,7H 4G                   Cheatgrass           4C,9H 3C,9H 6G    3C,8G 3G    0     0                    Wild Oats                                                                              6C,9G 5C,9G 8G    8G    3G    5G    0     0     0                    Wheat    5G    4C,9G 2C,8H 8G    2G    4G    0     0     0                    Corn     5C,9H 9G    9H    4C,9H 2C,9G 8G    2C,8H 3C,9H 4G                   Soybean  9H    9H    8H    9H    2C,5G 9H    3C,8H 3C,8H 5H                   Rice     10E   10E   10E   10E   3C,8H 4C,9H 3C,5H 3C,7G 0                    Sorghum  5C,9H 6C,9H 9H    3C,9H 3C,9H 4C,8H 3C,9H 5C,9H 2C,7G                Sugar beet                                                                             5C,9G 9C    5C,9G 5C,9G 5C,9G 9C    5C,9G 5C,9G 7G                   Cotton   2C,9G 9G    9G    9G    2C,8G 9G    3C,8G 8G    8G                   __________________________________________________________________________

What is claimed is:
 1. A compound of the formula ##STR55## wherein Q is##STR56## R is H or CH₃ ; R₁ is ##STR57## E is CH₂ or a single bond; R₂is H, C₁ -C₂ alkyl or Cl;R₃ is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy; R₄ andR₅ are independently C₁ -C₂ alkyl; R₆ and R₇ are independently H or C₁-C₂ alkyl; W is O; W₁ is O or S; Q₁ and Q₂ are independently O, S orNCH₃ ; A is ##STR58## P₁₁ is C₁ -C₃ alkyl; R₁₂ is H, F, Cl, NO₂, C₁ -C₂alkyl, C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂ alkylsulfinyl, C₁ -C₂alkylsulfonyl, di(C₁ -C₂)alkylsulfamoyl or CO₂ (C₁ -C₂ alkyl); R₁₃ is H,C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F or NO₂ ; R₁₄ is H, C₁ -C₃ alkyl, C₁-C₃ alkoxy, C₁ -C₃ haloalkyl, C₁ -C₃ haloalkoxy, Cl, Br, F, NO₂, di(C₁-C₃)alkylsulfamoyl, C₁ -C₃ alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃alkylsulfonyl, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, CH₂ OCH₃,CH₂ SCH₃ or CH₂ CN, Y₁ is O or CH₂ ; X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H;and Y₂ is H or CH₃ ;and their agriculturally suitable salts; providedthat (a) when R₃ is C₁ -C₃ alkoxy, then Q₁ and Q₂ are oxygen; (b) whenR₃ is H or C₁ -C₃ alkyl, then Q is Q-1 through Q-9; (c) when E is CH₂,then R₁₄ is H, CH₃, OCH₃, Cl or NO₂ and is not in the 4-position.
 2. Acompound of claim 1 where R₃ is H or C₁ -C₃ alkyl.
 3. A compound ofclaim 1 where R₃ is C₁ -C₃ alkoxy.
 4. A compound of claim 2 where R isH.
 5. A compound of claim 4 where Q₁ and Q₂ are identical and are O orS, R₁₂ is H, C₁ -C₂ alkyl or Cl and R₁₃ is H.
 6. A compound of claim 5where Q₁ and Q₂ are O.
 7. A compound of claim 5 where Q₁ and Q₂ are S.8. A compound of claim 5 where Q is Q-1.
 9. A compound of claim 5 whereQ is Q-2.
 10. A compound of claim 5 where Q is Q-3.
 11. A compound ofclaim 5 where Q is Q-4.
 12. A compound of claim 5 where Q is Q-5.
 13. Acompound of claim 5 where Q is Q-6.
 14. A compound of claim 5 where Q isQ-7.
 15. A compound of claim 5 where Q is Q-8.
 16. A compound of claim 5where Q is Q-9.
 17. A compound of claim 3 where R is H.
 18. A compoundof claim 4 where E is a single bond; R₁₂ is H, C₁ -C₂ alkyl or Cl; R₁₃is H; and R₁₄ is H, F, Cl, Br, C₁ -C₂ alkyl, C₁ -C₂ alkoxy or C₁ -C₂alkylthio and is not para to the sulfonylurea bridge.
 19. A compound ofclaim 19 where Q is Q-1.
 20. A compound of claim 19 where Q is Q-2. 21.A compound of claim 19 where Q is Q-3.
 22. A compound of claim 19 whereQ is Q-4.
 23. A compound of claim 19 where Q is Q-5.
 24. A compound ofclaim 19 where Q is Q-6.
 25. A compound of claim 19 where Q is Q-7. 26.A compound of claim 19 where Q is Q-8.
 27. A compound of claim 19 whereQ is Q-9.
 28. A compound of claim 19 where Q is Q-10.
 29. A compositionsuitable for controlling the growth of undesired vegetation whichcomprises an effective amount of a compound of claim 1 and at least oneof the following: surfactant, solid or liquid inert diluent.
 30. Acomposition suitable for controlling the growth of undesired vegetationwhich comprises an effective amount of a compound of claim 2 and atleast one of the following: surfactant, solid or liquid inert diluent.31. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 3and at least one of the following: surfactant, solid or liquid inertdiluent.
 32. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 4 and at least one of the following: surfactant, solid orliquid inert diluent.
 33. A composition suitable for controlling thegrowth of undesired vegetation which comprises an effective amount of acompound of claim 5 and at least one of the following: surfactant, solidor liquid inert diluent.
 34. A composition suitable for controlling thegrowth of undesired vegetation which comprises an effective amount of acompound of claim 17 and at least one of the following: surfactant,solid or liquid inert diluent.
 35. A composition suitable forcontrolling the growth of undesired vegetation which comprises aneffective amount of a compound of claim 18 and at least one of thefollowing: surfactant, solid or liquid inert diluent.
 36. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound ofclaim
 1. 37. A method for controlling the growth of undesired vegetationwhich comprises applying to the locus to be protected an effectiveamount of a compound of claim
 2. 38. A method for controlling the growthof undesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 3. 39. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound of claim4.
 40. A method for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 5. 41. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 17. 42. A methodfor controlling the growth of undesired vegetation which comprisesapplying to the locus to be protected an effective amount of a compoundof claim 18.